it is all up with

(informal)it is the end or there is no hope for (someone or something)

(非正式)對…，一切都完了

on the up and up informal 非正式

(Brit.)steadily improving or becoming more successful

(英)穩(wěn)步提高

(chiefly N. Amer.)honest or sincere

(主北美)誠實的，正直的

something is up

(informal)something unusual or undesirable is happening or afoot

(非正式)不尋常（或不好）的事發(fā)生了

up against it

(informal)facing some serious but unspecified difficulty

(非正式)面對某種困難，面臨某種困境

they play better when they're up against it.

面對困難時，他們打得更好。

up and about

no longer in bed (after sleep or an illness)

（睡眠或生病后） 起床；下床

up and doing

active; busy

忙碌的，積極肯干的

a normal young chap wants to be up and doing.

正常的年輕人總想積極向上。

up and down

moving upwards and downwards

一上一下，起伏

bouncing up and down.

上下跳動。

to and fro

來來回回，往返地

pacing up and down in front of her desk.

在她書桌前踱來踱去。

in various places throughout

到處，處處

in clubs up and down the country.

在全國各地俱樂部。

(informal)in varying states or moods; changeable

(非正式)（情緒，狀態(tài)）多變的

my relationship with her was up and down.

我和她的關(guān)系變化不定。

up and running

(especially of a computer system) in operation; functioning

（尤指計算機系統(tǒng)）運行中

the new computer is up and running.

新電腦在運行。

up the ante

the new computer is up and running.

新電腦在運行。

up before

appearing for a hearing in the presence of

出庭面對

we'll have to come up before a magistrate.

我們將不得不出庭面對治安法官。

up for

available for

正待

the house next door is up for sale.

隔壁房子正待出售。

being considered for

被考慮

he had been up for promotion.

他被考慮提升。

due for

到期

his contract is up for renewal in June.

他的合同將在六月到期續(xù)簽。

up for it

(informal)ready to take part in (a particular activity)

(非正式)準備參加

Nigel was really &B{up for it}, as always.

像平常一樣，奈吉爾真準備好參加了。

up hill and down dale

all over the place

到處

he led me up hill and down dale till my feet were dropping off.

他領(lǐng)著我到處走，直到我的腿都快斷了。

up top

(Brit. informal)in the brain (with reference to intelligence)

(英，非正式)頭腦里（指智力）

a man with nothing much up top.

大腦空空的人。